Pediatr Blood Cancer BRIEF REPORT Vacuolated Neuroblastoma Cells Mimicking FAB L3 Lymphoblasts in Bone Marrow Aspirates
نویسندگان
چکیده
Neuroblastoma is classically composed of small round blue cells forming pseudorosettes around fibrillary stroma. Prominent cytoplasmic vacuoles are a hallmark of the L3 subtype of acute lymphoblastic leukemia (ALL) in the French-American-British classification. Cytoplasmic vacuolation has also been observed in medulloblastoma [1], Ewing sarcoma, and rhabdomyosarcoma [2,3], but rarely described as a morphologic feature in primary neuroblastoma tumor tissue biopsies [4,5]. Hence, vacuolated metastatic neuroblastomamorphologically canmimic acute leukemia in bone marrow aspirate (BMA) smears, especially in cases where the bone marrow is replaced by non-cohesive tumor cells [6,7]. Here we describe two cases of metastatic neuroblastoma with significant cytoplasmic vacuolations of the neuroblasts.
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